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Drug Treatment of Metastatic Breast CancerFDA Approval OverviewPatricia Cortazar, MD Drugs approved for Metastatic Breast CancerMethotrexate 1953Cyclophosphamide 1959Thiotepa 1959Vinblastine 19615-Fluorouracil 1962Doxorubicin 1974 Paclitaxel 1994Docetaxel 1996Trastuzumab 1998Capecitabine 1998Capecitabine + Docetaxel 2001Abraxane 2005Lapatinib 2006Ixabepilone 2007Drugs approved in 2nd-3rd line Metastatic Breast Cancer PaclitaxelTAXOL? is indicated for the treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse w