血管内治疗术后恶性脑水肿的研究进展.pdfVIP

中文科技期刊数据库（全文版）医药卫生 血管内治疗术后恶性脑水肿的研究进展 胡雨蒙 段晓聪 武一平(通讯作者) 张邯菲 王旭东 1.邯郸市中心医院神经内科，河北 邯郸 056001 2.承德医学院，湖北 承德 067000 摘要：急性缺血性卒中（Acute ischemic stroke，AIS）是全球最为重要的健康威胁因素之一，其致残率与致死 率较高。研究表明，若在本病超早期接受及时有效的再灌注治疗，患者预后将会有明显改善。恶性脑水肿形成后 病死率可高达80%。而对于颅内大血管闭塞的急性缺血性脑卒中(AIS)患者,以机械取栓为主的血管内多模式方法 治疗可带来明显获益。本文主要阐述恶性脑水肿的形成机制、预测因素的新进展。 关键词：急性缺血性卒中；恶性脑水肿；血管内治疗；血脑屏障 中图分类号：R739.41 Progress in studying malignant cerebral oedema after mechanical thrombectomy HU Yumeng DUAN Xiaocong WU Yiping(corresponding author) ZHANG Hanfei LIU Jun WANG Xudong 1.Department of Neurology , Handan Central Hospital ，Hebei Handan 056001 2.Chengde Medical University ，Hebei Chengde 067000 Abstract ：Acute ischemic strokeis one of the most important health threats in the world, with high disability and mortality rates. Studies have shown that if timely and effective reperfusion treatment is received in the very early stage of this disease, the patient prognosis will be significantly improved. The case fatality rate after malignant cerebral edema can be as high as 80%. For patients with acute ischemic stroke (AIS) with intracranial large vessel occlusion, the endovascular multimodal approach based on mechanical thrombectomy can bring significant benefits. This paper mainly describes the mechanism and the formation factors of malignant cerebral edema. Keywords ：Acute ischaemic stroke; malignant cerebral edema; endovascular treatment; blood brain barrier 恶性脑水肿是血管内治疗（endovascular 定更有价值的治疗方案。 treatment，EVT）术后的严重并发症，其特征为伴有 1 恶性脑水肿的形成机制 严重脑水肿的恶性病程，可导致脑疝发生引起死亡或 恶性脑水肿的形成是一个复杂的液体交换过程， 严重神经系统功能障碍，最常见于恶性脑水肿形成后