低强度聚焦超声联合载药微泡靶向治疗兔肝VX2肿瘤的实验研究的中期报告.docxVIP

低强度聚焦超声联合载药微泡靶向治疗兔肝VX2肿瘤的实验研究的中期报告 摘要： 本研究旨在探讨低强度聚焦超声（LIFU）联合载药微泡靶向治疗兔肝VX2肿瘤的可行性和安全性。采用VX2兔模型建立了肝肿瘤模型，将均质化的载药微泡注入肝动脉，然后在肝区进行LIFU治疗。中期实验结果显示，LIFU联合载药微泡治疗组的肿瘤体积显著减少，包膜完整，组织结构紧密，与对照组比较差异显著。同时，在治疗组中未出现明显的毒副作用，证明了本研究方法的可行性和安全性。 关键词：低强度聚焦超声；载药微泡；肝肿瘤；VX2兔模型；靶向治疗 Abstract: The aim of this study is to investigate the feasibility and safety of low intensity focused ultrasound (LIFU) combined with drug-loaded microbubbles targeting treatment of rabbit liver VX2 tumor. A VX2 rabbit model was used to establish a liver tumor model. Homogeneous drug-loaded microbubbles were injected into the hepatic artery, and then LIFU treatment was performed in the liver area. The midterm experimental results showed that the tumor volume in the LIFU combined with drug-loaded microbubbles treatment group was significantly reduced, the envelope was intact, and the tissue structure was tight, which was significantly different from the control group. At the same time, there were no significant toxic and side effects in the treatment group, which proved the feasibility and safety of this research method. Keywords: Low intensity focused ultrasound; drug-loaded microbubbles; liver tumor; VX2 rabbit model; targeted therapy.