药理学教学课件：第十五章 镇静催眠药 　.pptVIP

正常的GABA抑制下，冲动可以正常传到，过度抑制后，冲动无法传达。 Benzodiazepine Antagonist The drug flumazenil（氟马西尼） binds with high af nity to the benzodiazepine receptor but lacks any agonist activity. Consequently, the receptor is occupied and unavailable for binding of benzodiazepine agonists. Flumazenil is a specific antidote and is used with success for reversal of benzodiazepine toxicity or to terminate benzodiazepine sedation. When patients suffering from benzodiazepine dependence are given flumazenil, withdrawal symptoms are precipitated. Flumazenil is eliminated relatively rapidly with a t?of ~ 1 hour. Therefore,