噪声习服机制的研究进展及临床应用前景.pdfVIP

·659 · ChineseJournalofOtologyVo1.20,No.4,2022 ·综 述 · 噪声习服机制的研究进展及临床应用前景 赵锐 安俊俊 石林* 大连医科大学附属第一医院耳鼻喉科（大连 116000） 【摘要】噪声习服即在给动物高强度噪声暴露之前，先给予低水平、无破坏性的声音刺激，从而减少随后高强 度噪声引发的暂时性或永久性听力阈移。其机制不明，目前研究报道噪声习服是通过保护毛细胞、激活下丘脑- 垂体-肾上腺轴(Thehypothalamic-pituitary-adrenalaxis,HPAorHTPAaxis)、氧化应激及代谢调节等机制发挥保护 作用。因此学者们进行大量研究，探索应用噪声习服预防、干预各种理化因素引起的听力下降。本文总结了噪声 习服的作用机制及动物实验的相关研究进展，从理论上探讨噪声习服临床应用的可行性，为后续研究及临床治疗 提供重要的参考。 【关键词】噪声习服；氧化应激；噪声性耳聋;老年性聋；应用前景 【中图分类号】R764 【文献标识码】A 【文章编号】1672-2922（2022）04-659-4 Research Progress on Mechanisms of Sound Conditioning and Prospects for Clinical Application ZHAO Rui, AN Junjun, SHI Lin* Department of Otorhinolaryngology, First Affiliated Hospital of Dalian Medical University ，Dalian 116000 ，China Corresponding author: SHI Lin Email:shilin516@ 【Abstract 】In sound conditioning, animals are exposed to low-level sound stimuli prior to noise exposure to re‐ duce hearing threshold shift induced by high-intensity noise. The mechanism of sound conditioning is unknown. Current research reports believe that sound conditioning plays a protective role by protecting hair cells, activating the (The hypo‐ thalamic-pituitary-adrenal axis ,HPA or HTPA axis) axis, regulating oxidative stress, and so on. Scholars have conducted a large number of studies to explore the application of sound conditioning in preventing and treating hearing loss caused by various physical and chemical factors. This article summarizes on the mechanism of sound conditioning and progress in related research including animal experiments, and theoretically explores the feasibility of the clinical appli