分子生物学：Section N 真核生物的转录调控.pptVIP

HIV genome N2-5: Cell determination: myoD myoD was identified as a gene to regulate gene expression in cell determination, commanding cells to form muscle. MyoD protein has been shown to activate muscle-specific gene expression directly. Overexpression of myoD can turn fibroblasts into muscle-like cells which express muscle-specific genes and resemble myotomes. myoD also activates expression of p21waf1/cip1 expression, a small molecule inhibitor of CDKs, causing cells arrested at the G1-phase of the cell cycle which is characteristic of differentiated cells. Four genes, myoD, myogenin, myf