分子生物学：F DNA损伤、修复与重组.pptVIP

* Homologous recombination during double-stranded break repair (DSBR) is essentially the same as during meiosis. All steps of strand invasion, D-loop formation and Holliday junction formation, as well as strand migration are equivalent. The main difference is the resolution of Holliday junctions at the end of the recombination. Because DSBR does not require crossing-over, resolution is much simpler. Two nicks are made in each Holliday junction. These loose ends are then reattached in a combination that removes pairing between the chromosomes. * Homologous recombination occurs in other co