4689平均加权采集可更快地大脑体内局部二维相关光谱.pdfVIP

Average weighted acquisition for fas cquisition of in vivo localized two dimensional correlation spectroscopy of the brain 1 2 1 Gaurav Verma , Michael Albert Thomas , and Harish Poptani 1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Radiology, University of California at Los Angeles, Los Angeles, CA, United States Introduction: Two-dimensional (2D) ma ic resonance spectroscopy (MRS) methods like localized correlated spectroscopy (L-COSY) (1,2) have demonstrated the capacity to uniquely resolve more metabolites than one-dimensional (1D) alternatives. Clinical adoption of these sequences has thus far been limited, however due to the need to acquire multiple t1 rements, resulting in long sc s. Average-weighting could improve the acquisition efficiency of L-COSY, facilitating faster scans without a commensura oss of signal quality. Average-weighting matches signal averaging to the signal quality expected from each t1 rement rather than uniformly averaging each rement equally. These techniques could be made even more versatile for specific applications by optimizing averaging schemes for the expected signal only from particular metabolites. The purpose of this study was to implement average-weighted L-COSY and demonstrate its improved acquisition efficiency and versatility. Materials Methods: Average-weighted L-COSY sequences were developed for human brain and a phantom containing sixteen brain metabolites at physiological concentration. Average-weighting schemes were empirically-optimized by yzing the signal-to-noise ratio (SNR) of ea etabolite while sequentially varying the averages of the