CSF-1R和VEGF在喉癌中的表达及与淋巴结转移的关系的中期报告.docxVIP

CSF-1R和VEGF在喉癌中的表达及与淋巴结转移的关系的中期报告 摘要： 喉癌是一种常见的头颈部恶性肿瘤，具有较高的淋巴结转移率。本研究旨在探讨CSF-1R和VEGF在喉癌中的表达及与淋巴结转移的关系。我们对54例喉癌患者的肿瘤组织标本进行了免疫组化染色，并使用统计学方法分析了CSF-1R和VEGF表达和淋巴结转移之间的关系。 结果显示，CSF-1R和VEGF在喉癌中高表达，并且表达水平与淋巴结转移有密切关系。具体而言，CSF-1R和VEGF的表达水平与淋巴结转移呈正相关（P0.05）。此外，我们还发现，淋巴结转移的扩散越明显，肿瘤组织中CSF-1R和VEGF的表达水平越高。 综上所述，CSF-1R和VEGF在喉癌中的高表达与淋巴结转移有密切关系，提示CSF-1R和VEGF可能作为喉癌淋巴结转移的标志物。这些结果有望为喉癌的早期诊断和治疗提供新的理论依据。 关键词：喉癌；CSF-1R；VEGF；淋巴结转移；标志物 Abstract: Laryngeal cancer is a common malignant tumor in head and neck with high frequency of lymph node metastasis. The aim of this study was to investigate the expression of CSF-1R and VEGF in laryngeal cancer and their correlation with lymph node metastasis. We performed immunohistochemical staining on tumor tissue samples from 54 patients with laryngeal cancer and analyzed the relationship between CSF-1R and VEGF expression and lymph node metastasis using statistical methods. The results showed that CSF-1R and VEGF were highly expressed in laryngeal cancer and the expression levels were closely related to lymph node metastasis. Specifically, the expression levels of CSF-1R and VEGF were positively correlated with lymph node metastasis (P0.05). In addition, we found that the higher the degree of lymph node metastasis, the higher the expression levels of CSF-1R and VEGF in tumor tissue. In conclusion, the high expression of CSF-1R and VEGF in laryngeal cancer is closely related to lymph node metastasis, suggesting that CSF-1R and VEGF may be biomarkers for lymph node metastasis in laryngeal cancer. These results may provide a new theoretical basis for the early diagnosis and treatment of laryngeal cancer. Keywords: laryngeal cancer; CSF-1R; VEGF; lymph node metastasis; biomarker