非传统血脂指标与动脉粥样硬化性心血管疾病风险管理中国专家共识.pdfVIP

非传统血脂指标与动脉粥样硬化性心血管 疾病风险管理中国专家共识 中国中西医结合学会检验医学专业委员会 通信作者：袁慧，首都医科大学附属北京安贞医院检验科，北京 100029，Email： 189.cn 【摘要】 动脉粥样硬化性心血管疾病是以动脉粥样硬化为病理基础的一系列疾病的总称，随着 中国社会经济的发展和人口老龄化的进展，动脉粥样硬化性心血管疾病负担日益加重。近年来一些 临床研究证明，包括低密度脂蛋白胆固醇在内的传统血脂指标在动脉粥样硬化性心血管疾病的风险 管控方面表现出一定的局限性，血脂指标还需进一步补充完善。本共识从检验和临床两个角度系统 阐述了非传统血脂指标，主要包括载脂蛋白B和脂蛋白a、非高密度脂蛋白胆固醇和脂蛋白残粒及非 空腹血脂。对非传统血脂指标的病理生理机制、与心血管疾病之间的关系、检测方法及性能、以及在 动脉粥样硬化性心血管疾病风险管理中的应用进行了系统阐述，并给出了相应的临床专家指导意见。 【关键词】 血脂异常； 动脉粥样硬化； 心血管疾病； 非传统血脂指标； 风险管理 基金项目：吴阶平医学基金（320.6750.2021‑06‑1） Chineseexpertconsensusonnon‑traditionalbloodlipidparameterstocontroltherisksof arteriosclerotic cardiovascular disease The Specialist Committee on Laboratory Medicine of Chinese Association of Integritive Medicine Corresponding author: Yuan Hui, Department of Clinical Laboratory, Beijing Anzhen Hospital, Beijing 100029, Email:189.cn 【Abstract 】 Atherosclerotic cardiovascular disease is the general name of a series of diseases based on atherosclerosis. With the development of the social economy and the progress of population aging in China, the burden of atherosclerotic cardiovascular disease is increasing. However, in recent years some clinical studies have proved that the traditional blood lipid indicators, including low‑density lipoprotein cholesterol, have some limitations in the risk control of atherosclerotic cardiovascular disease, and the blood lipid indicators need to be further supplemented and improved. Thisconsensusexpoundsnon‑traditionalbloodlipidindexesfromthe perspectives of test and clinic, mainly including apolipoprotein B and lipoprotein a, non‑highdensity lipoprotein cholesterol and lipoprotein residue, and non‑fasting blood lipid. This consensus systematicallyexpoundsthepathophysiologicalmechanismofnon‑traditionalbloodlipidindexes, the relationship with cardiovascular disease, detection methods and performance, intervention, control and application in the state of cardiovascular disease, and giv