给药系统设计及分子学基础.pptVIP

* Case File — Sediment Osmotic pump tablet 1975: Elementary osmotic pump 1982: Two-layer push–pull 1989: Three-layer DRUG DRUG DRUG DRUG DRUG DRUG 本文档共63页；当前第30页；编辑于星期二\18点54分 * Model drug: Famotidine (FMTD) 法莫替丁 prolonged antisecretory effect in the therapy of duodenal, gastric, and peptic ulcer low solubility 25 g/ml relatively short elimination half-life time (about 3 h) in humans as well as low bioavailability(45–50%) Case File — Sediment 本文档共63页；当前第31页；编辑于星期二\18点54分 * Materials Case File — Sediment Polyethylene oxide (PEO) Mw 1,000,000 (WSR N12K) Pharmaceutical iron powder (100 mesh) NaCl Cellulose acetate (CA) Acetone Polyethylene glycol 4000 (PEG 4000) Technetium-99m (99mTcO4?) Commercially available FMTD conventional tablets High density gastric resident osmotic pump tablet Coating material 本文档共63页；当前第32页；编辑于星期二\18点54分 * Case File — Sediment Central composite design PEO (X1) NaCl (X2) Pharmaceutical iron powder (X3) Coating weight gain of the tablet (X4) 4 factor 5 level 本文档共63页；当前第33页；编辑于星期二\18点54分 * Sediment Y1 The critical responses were ultimate cumulative release in 12 h Y2 Correlation coefficient of drug release profile Central composite design 本文档共63页；当前第34页；编辑于星期二\18点54分 * PEO (X1) NaCl (X2) Pharmaceutical iron powder (X3) Coating weight gain of the tablet (X4) Y1 Ultimate cumulative release in 12 h Y2 Correlation coefficient of drug release profile Case File — Sediment 本文档共63页；当前第35页；编辑于星期二\18点54分 * PEO (X1) NaCl (X2) Pharmaceutical iron powder (X3) Coating weight gain of the tablet (X4) Y1 Ultimate cumulative release in 12 h Y2 Correlation coefficient of drug release profile Case File — Sediment 本文档共63页；当前第36页；编辑于星期二\18点54分 * PEO (X1) NaCl (X2) Pharmaceutical iron powder (X3) Coating weight gain of the tablet (X4) Y1 Ultimate cumulative release in 12 h Y2 Correlation coefficient of drug release profile Case File — Sediment 本文档共63页；当前第37页；编辑于星期二\18点54分 * Opti