神经退行性疾病干细胞移植治疗目前研究现状与未来展望.pptxVIP

神经退行性疾病干细胞移植治疗目前研究现状与未来展望 胎儿神经干细胞治疗帕金森氏病临床研究发展历程Evans JR, Mason SL, Barker RA、 Prog Brain Res、 2012;200:169-98 Lindvall O, et al,Nat Med、 2008 May;14(5):501-3THSynucleinOverlayTransplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons Synuclein-HostUbiquintin-HostSynuclein-Grafted NeuronsUbiquintin-Grafted NeuronsGrafted nigral neurons were found to have Lewy body-like inclusions14 years after transplantation into the striatum of an individual with PDOlanow CW、 et al Nat Med、 2008May;14(5):504-6、 Transplanted dopamine neurons in people with PD do not contain Lewy bodiesMendez, Isacson et al, , NATURE MEDICINE VOLUME 14 (5):507-509, 2008 Freed CR, J Nucl Med、 2010 Jan;51(1):7-15 - Long term Study- 33 of the original trial participants who were followed for 2 years after transplantation and 15 of these subjects who were followed for 2 additional years、 - These results suggest that clinical benefit and graft viability are sustained up to 4 y after transplantation、 Freed CR, Neurotherapeutics (2011) 8:549 –561 人体胚胎干细胞分化得多巴胺神经元移植改善小鼠,大鼠和猴子帕金森氏病得运动障碍22/29 DECEMBER 2011 | VOL 480 | NATURE | 547,Lorenz Studer,et al Memorial Sloan-Kettering Cancer Center Improved Cell Therapy Protocol for Parkinson’s Disease Based on Differentiation Efficiency and Safety of hESC-, Hipsc and Non-Human Primate iPSC-Derived DA NeuronsIsacson et al, , Stem Cells、 2013 ;31(8):1548-62、 Dopamine release from transplanted neural stem cells in Parkinsonian rat striatum in vivo、  Zhou z, et al, Proc Natl Acad Sci U S A、2014 Nov 4;111(44):15804-9 iPSC-Derived Dopamine Neurons function after Transplantation in a Non-Human Primate Model of Parkinson’s Disease Cell Stem Cell、 2015 Mar 5;16(3):269-74、 Ole Isacson et al,Harvard Stem Cell Institute 11大家应该也有点累了，稍作休息大家有疑问的，可以询问和交流 Stem cell-based Clinical Trials for (ALS) Nuralstem, In c 、 the first Phase I clinical trial for a stem cell-based treatment of ALS、 Initiated i