人体寄生虫学：蓝氏贾第鞭毛虫.pptVIP

蓝氏贾第鞭毛虫蓝氏贾第鞭毛虫(Giardialamblia)——人体小肠上段寄生性原虫引起腹泻和吸收不良——Giardiasis以旅游者、儿童、免疫力低下者易感。形态和生活史1.滋养体2.包囊?

GiardialambliaParasiteresidessmallintestine(duodenum),gallbladder,causinggiardiasisor‘touristdiarrheaGiardialambliaisconsideredtobeoneofthemajorcauseofparasiticdiarrheaMorphologyTrophozitepear-like,rangesfrom8-16?minlengthby5-12?minwidethbilaterallysymmetric,thedorsalsurfaceisconvex,concaveventrallywithsuckingdiscadhesivediscwithanucleusinthecenterofeachhalffourpairsofflagellaissupportedbyanaxostyletwocurvedmedianbodiesinthemiddleofaxostyle

Cystfootballshaped,wellthickfournucleiarevisibleinmature,inadditiontofibrilsmedianbodies,immaturecysthasonlytwonuclei

生活史4核包囊包滋养体包囊四核包囊是感染期经口

LifecycleHumaninfectionmainlyresultsfromingestionmaturecyst-contaminatedfoodorwaterExcystationoccursintheupperregionsofthesmallintestine,wherethetrophozoiteresidesmultipliesbybinaryfissiontrophozoitesmayalsolocateinthecommonbileductandthegallbladderTrophozoitespassthroughthedigestivetract,encystinthecolontransformedintocysts,passinthefecescystswithhighlyresistantquadrinucleatecysttrophozitecyst

致病大多数病人无症状。症状则主要有呕吐,腹泻、腹胀、水样便，量大，恶臭但无脓血。Normalvilliofsmallintestine.Flattened,fusedvillifrompatientwithG.lamblia.

A25yearoldmanpresentedtoahospitalclinicwitha2weekhistoryofsustaineddiarrhea(threetofivebowelmovementperday),nausea,flatulence,andlackofappetite.Hedescribedhisdiarrheaasinitiallywatery,andthengreasyandfoulsmelling.Headdedthathehadabloatingsensation.Hedidnothavefeverorchills.Thepatienthadbeeningoodhealth.Fourweeksprevioustoseeinghisphysician,hehadvisitedaruraltownforseveraldays.Physical