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- 2024-04-09 发布于广东
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*InitiallytheparathyroidglandsrespondtothealteredmineralmetabolisminCKDbyincreasingPTHsecretionandsynthesis.However,asthealteredlevelsofcalcium,phosphorus,andvitaminDpersist,theparathyroidglandsrespondbyincreasingthenumberofcells(cellproliferation),whichresultsinanincreaseinglandsize(hypertrophy/glandenlargement).ThisresultsinanincreaseinthenumberofcellsavailabletoproducePTH.1Afterthisinitialincreaseinthenumberofactivechiefcells,diffusehyperplasiamaydevelopfollowedbynodularhyperplasia.1,2Nodularcellsarea
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