此为英文文档：who -GRADE tables for malaria vaccines, 2023.docx

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Author(s):VillanuevaG,SebastianskiM,ProbynK,HenschkeN

Question:Shouldamalariavaccinebeprovidedtoreducemalariadiseaseburdeninchildren≥5monthsofagelivinginregionswithendemicmalariatransmission?

Population:Children≥5monthsofage

Intervention:Malariavaccination

Comparison:Malariapreventioninterventionscurrentlyinplacewithoutmalariavaccination

Setting:regionswithendemiclow,moderate,orhighmalariatransmission

Outcome

Comparison

Studydesign

№ofparticipants

Relative

effect

(95%CI)

Absoluteeffects

(95%CI)

Certainty

Comments

Vaccination

Control

Control

Riskdifferencewithmalariavaccination

CLINICAL

MALARIA

(Impact,criticaloutcome)

Age-basedadministration(year-rounddeliveryofall4dosesbasedonchild’sage)

RTS,S/AS01versuscontrol1

Ph3randomised

trial;2009-2014

(month0toend

ofstudy;median

48months’

follow-up)

N=2976;6616episodes

N=2974;

9585

episodes

VE:36.3%

(31.8to

40.5)2

Studypopulation

。。。。HIGH

RTS,S/AS01

vaccinationreducesclinicalmalaria

episodes

1774fewercasesper1000

children

(1387fewerto2186fewer)3

Lowtransmission4

205-303fewercasesper1000children

Moderatetransmission5

15950totalparticipants:four-dosegroup=threedosesofRTS,S/AS01atmonths0,1,and2andaboosterdoseatmonth20;Controlgroupreceivedcomparatorvaccineatmonths0,1,2,and202ModifiedITTanalysisVE(participantsreceivingatleast1vaccinedose,withfollow-upfromdose1);PPanalysisVE:39%(34.3%to43.3%)

3Inchildrenaged5-17months,1363casesofclinicalmalariawereavertedper1000children(95%CI995-1797)intheR3Cgroup

4RTS,S/AS01Phase3lowtransmissionsites:Kilifi,KenyaandKorogwe,Tanzania

5RTS,S/AS01Phase3moderatetransmissionsitesLambarene,Gabon;Bagamoyo,Tanzania;Lilongwe,Malawi;Manhi?a,Mozambique

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Outcome

CLINICAL

MALARIA

(Impact,criticaloutcome)

Comparison

Comparison

Studydesign

№ofparticipants

Relative

Relative

effect

(95%CI)