分子医学 感染免疫的分子机制与疾病A.pptVIP

MyD88knockoutmicehavenoresponsetoLPSMyD88isessentialtoallinflammatorysignalingpathwaysMyD88s,asplicevariantofMyD88downregulatestheinflammatoryresponseMyD88interactswithTIRdomainofTLRandrecruitsIRAK-4,IRAK-1andTRAF-6MyD88AdaptorRakoff-Nahoumetal.,RecognitionofcommensalmicroflorabyToll-likereceptorsisrequiredforintestinalhomestasis.Cell118:229-41,2004.4IRAKsknown,IRAK1,IRAK-2,IRAK-MandIRAK-4IRAKareserine/threoninekinasesIRAK-4phosphorylatesIRAK-1IRAK-MplaysaninhibitoryroleinTLRsignalingTRAF6isamemberof