Period2调节小鼠心肌梗死后血管新生的作用及机制研究中期报告.docxVIP

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Period2调节小鼠心肌梗死后血管新生的作用及机制研究中期报告.docx

Period2调节小鼠心肌梗死后血管新生的作用及机制研究中期报告

Abstract

Myocardialinfarction(MI)isacommoncardiovasculardiseasethatoftenleadstoheartfailureanddeath.Vascularendothelialgrowthfactor(VEGF)playsacrucialroleinpromotingangiogenesisandmaintainingcardiacfunctionafterMI.Period2(Per2)isacircadianclockgenethatregulatesdiversebiologicalprocesses,includingendothelialcellfunction.However,theroleofPer2inpost-MIangiogenesisremainsunclear.Inthepresentstudy,weaimtoinvestigatetheeffectofPer2onpost-MIangiogenesisandexploretheunderlyingmechanisms.

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