间质干细胞及急性肺损伤.pptVIP

BALalbumin,totalprotein,andimmunoglobulinM(IgM)wereincreased3daysfollowingintratrachealLPS.ThisincreasewasattenuatedbyMSCsgivenintravenously30minutesaftertheinjury.Angiopoietin-1mayhelpmaintainadultvascularendothelialcellsinaquiescentstate,reducepermeabilityandpromoteendothelialcellsurvivalLPS注入气管内3天后肺泡灌洗液中白蛋白、总蛋白和免疫球蛋白M(IgM)增加。ALI静脉注射MSC30min，可以减轻蛋白含量。血管生成素维持血管内皮细胞处于静止状态，同事减少渗透性,促进内皮细胞的存活。第31页,共59页，星期六，2024年，5月MSCsproduceAng-1furtherreducedBALprotein,albumin,andIgM。Ang-1diminishinginflammatorycellinfluxandredu