中药加化疗对大肠癌术后复发转移的影响研究.docxVIP

?

?

中药加化疗对大肠癌术后复发转移的影响研究

?

?

R735A1672-5085（2011）39-0070-03

【摘要】目的探讨中药联合化疗治疗大肠癌术后复发转移的临床疗效。方法将2003年6月～2008年6月我科收治的134例大肠癌术后患者随机分为单纯化疗组（67例）和中药联合化疗组（67例）。观察患者化疗期间的不良反应及术后1、2、3年复发转移率，同时采用Karnofsky评分标准评估患者化疗前后的生活质量。结果两组患者术后1，3年复发转移率无显著性差异（P0.05），而术后2年，联合化疗组的复发转移率显著低于单纯化疗组，差异有统计学意义(P0.05)。治疗前后比较，两组Karnofsky评分均显著提高，差异有统计学意义(P0.05)；治疗后比较，联合化疗组Karnofsky评分明显高于单纯化疗组，差异有统计学意义(P0.05)。两组的胃肠道反应比较，差异有统计学意义（P0.05），其他不良反应无显著性差异（P0.05）。结论中医药联合化疗治疗大肠癌术后患者，可减轻化疗毒副反应，降低肿瘤的复发转移，改善患者生活质量。

【关键词】中医疗法化疗大肠癌术后健脾消癌饮

ThecliniceffectofchemotherapycombinedwithChinesemedicineinpreventingrecurrenceandmetastasisofpostoperativecolorectalcancer

【Abstract】Objective：ToexploreclinicaleffectofchemotherapycombinedwithChinesemedicineinpreventingrecurrenceandmetastasisofpostoperativecolorectalcancer.Methods：134casesofpostoperativecolorectalcancerpatientswhoreceivedtreatmentinourhospitalfrom2003.6～2008.6wererandomlypidedintotwogroups,including67casesofchemotherapygroup,67casesofcombinedgroup.The1-year,2-year,3-yearrecurrenceandmetastasisrateafteroperationandthemaintoxicitiesinchemotherapyperiodwereobserved,andthequalityoflifewasassessedbyKarnofskyscoresbeforeandaftertreatment.Result：1-year,3-yearrecurrenceandmetastasisrateafteroperationwerenotsignificantlydifferent(P0.05),whilethedifferencewassignificantat2-yearafteroperation(P0.05).Afterchemotherapytreatment,thescoreofKarnofskywassignificantlyhigherthanthosebeforetreatment,andthescoreofKarnofskyincombinedgroupwereincreasedmoreremarkedlythanthoseinchemotherapygroup(P0.05).Themaintoxicitiesofgastrointestinalsymptomsincombinedgroupwassignificantlylowerthanthatinchemotherapygroup(P0.05),whiletherewasnosignificantdifferenceonothertoxicitiesbetweenthetwogroups(P0.05).Conclusions:ChemotherapycombinedwithChinesemedicinefortreatmentofpostoperativecolorectalcancercancontributetoreducethetoxicitiesofchemotherapyandtherateofrecurrenceandmetastasis,andimprovethequalityoflife.

【Keywords】ChinesemedicinetherapyChemotherapyPostoperativecolorectalcancerJianpixiaoaidecocti