替勃龙或雌孕激素治疗对绝经后妇女血脂及血清同型半胱氨酸水平的影响.pdfVIP

替勃龙或雌孕激素治疗对绝经后妇女血脂及血清同型半胱氨酸水平的影响--第1页

替勃龙或雌孕激素治疗对绝经后妇女血脂及血清同型半胱氨酸

水平的影响

刘颖;孙洁;杨珺;陈波

【摘要】目的:探讨绝经后妇女应用替勃龙或雌孕激素治疗后对其血脂代谢和血清

同型半胱氨酸(Hcy)水平的影响.方法:回顾性分析妇科门诊305例45～60岁绝经

后妇女,根据是否用药和应用药物种类不同分为替勃龙组、雌孕激素治疗组和对照

组,对其血清雌激素、血脂水平和血清Hcy检测结果进行分析.结果:基线情况各组

比较均无统计学差异(均P＞0.05),替勃龙治疗组和雌孕激素治疗组的血清甘油三酯

水平显著低于对照组,血清Hcy在雌孕激素治疗组显著低于替勃龙组和对照组(均P

＜0.05);替勃龙组与对照组比较,血清Hcy水平无统计学差异(P＞0.05).结论:对于绝

经后妇女应用雌孕激素治疗或替勃龙均可以改善血脂代谢,雌孕激素治疗可以降低

血清同型半胱氨酸水平,替勃龙对其无影响.%Objective:Toexploretheeffectsof

Tiboloneandmenopausalhormonetherapy(MHT)onlipidmetabolism

andserumhomocysteine(Hcy)inpostmenopausalwomen.Methods:Three

hundardandfivecasesof45-60ypostmenopausalwomenwererecruited

fromoutpatientsinChina-JapanFriendshipHospital.Theyweredivided

into3groupsaccordingtothemedicinetheytook.InTibolonegroupthey

tooktibolone.Inestrogenprogestogentherapy(EPT)grouptheytook

estradiol/cyproteroneorestradiol/dydrogesteroneforoverhalfayear.In

controlgrouptheytooknoneofthesekindofmedicine.Thefollowing

parametersweremeasured:serumconcentrationsof

E2,FSH,FPG,CHO,TG,HDL,LDLandHcy.Results:Age,E2,FSHwereno

significantdifferenceinthreegroups(P＜0.05).ThelevelsofTGwere

替勃龙或雌孕激素治疗对绝经后妇女血脂及血清同型半胱氨酸水平的影响--第1页

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significantlydecreasedintibolonegroupandEPTgroupcomparedwith

controlgroup.EPTgroupcansignificantlydecreaseHcylevelcompared

withtiboloneandcontrolgroup(P＜0.05).Conclusion:TiboloneorEPTused

inpostmenopausalwomencanimprovelipidmetabolism,EPTmay

decreaseHcylevel,butthislevelwasnotaffectedintibolonegroup.

【期刊名称】《中日友好医院学报》

【年(卷),期】2017(031)003

【总页数】3页(P142-144)