mcK6A1-生命科学试剂-MCE.pdf

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mcK6A1

Cat.No.:HY-P10876

分⼦式:C₇₁H₉₉N₁₇O₁₆

分⼦量:1446.65

Sequence:cyclo{{Orn}-Thr-Leu-Trp-Tyr-Lys-{δ-Orn}-{hydrazine-(5-Amino-

2-methoxybenzoicacid)-(oxalicacid)}-Lys-Tyr}

SequenceShortening:cyclo{{Orn}-TLWYK-{δ-Orn}-{hydrazine-(5-Amino-2-

methoxybenzoicacid)-(oxalicacid)}-KY}

作⽤靶点:Amyloid-β

作⽤通路:NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性mcK6A1是抑制淀粉样蛋⽩-β(Aβ)聚集的抑制剂，能够选择性地与Aβ42的16KLVFFA21⽚段结合，形成

延伸的β折叠结构，并抑制Aβ42寡聚体的形成。mcK6A1可⽤于阿尔茨海默病和其他淀粉样蛋⽩相关疾病

的研究[1]。

REFERENCES

[1].LuJ,etal.,Structure-BasedPeptideInhibitorDesignofAmyloid-βAggregation.FrontMolNeurosci.2019Mar4;12:54.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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