22 edwards sapien in native mitral annular calcification在天然二尖瓣环形钙化中.pdfVIP

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22

EdwardsSAPIENinNativeMitralAnnularCalcification(MAC)

12112

MayraGuerrero,DeeDeeWang,MackramEleid,CharanjitRihal,WilliamO’Neill,

andTedFeldman3

1DepartmentofCardiovascularMedicine,MayoClinicHospital,Rochester,MN,USA

2DivisionofCardiologyandCenterforStructuralHeartDisease,HenryFordHospital,Detroit,MI,USA

3EdwardsLifesciences,Irvine,CA,USA

22.1IntroductionSantaRosa,CA)

[15],aswellasongoingclinical

trialswithnewdedicatedmitralTHVssuchas

PatientswithsymptomaticseveremitralvalveTendyne(AbbottVascular,SantaClara,CA)and

diseaseinthesettingofseveremitralannularIntrepid(MedtronicInc.,RedwoodCity,CA).

calcification(MAC)areoftenelderlywithmulti-

plecomorbiditiesandhavehighriskofcardio-

vasculardeath

[1–3].Theiroperativeriskfor22.2Anatomic

standardmitralvalvesurgeryisusuallyhighdueConsiderationsand

Sizing

tocomorbiditiesandtechnicalchallengessec-

ondarytoseverecalcification

[4,5].DuetotheirThereareimportantanatomicfeaturesthat

highsurgicalrisk,manyofthesepatientsarenotshouldbetakeninconsiderationtoachievea

offeredstandardmitralvalvereplacement.successfulTMVRforMACusingaballoon-

Transcathetermitralvalvereplacement(TMVR)expandableaorticTHV.First,themitralannu-

withthecompassionateuseofaortictranscath-lusisnoncircular,butratherhasacomplex

eterheartv