老年期痴呆的BPSD非药物治疗及其与ApoE基因多态性相关性.docx

老年期痴呆的BPSD非药物治疗及其与ApoE基因多态性相关性的临床研究

[中图分类号]?R749??????[文献标识码]?A????[DOI]?10.3969/j.issn.1673-9701.2024.04.001

Clinical?study?on?non-drug?treatment?of?BPSD?in?senile?dementia?and?its?correlation?with?ApoE?gene?polymorphism

ZHU?Ye

Department?of?Neurology，?Jiangxi?Provincial?Peoples?Hospital，?the?First?Affiliated?Hospital?of?Nanchang?Medical?College，?Nanchang?330006，?Jiangxi，?China

[Abstract]?Objective?To?analyze?the?effect?of?non-drug?therapy?on?behavioral?and?psychological?symptom?of?dementia?（BPSD）?and?its?correlation?with?apolipoprotein?E?（ApoE）?gene?polymorphism.?Methods?A?total?of?90?patients?with?senile?dementia?admitted?to?Jiangxi?Provincial?Peoples?Hospital?from?January?2016?to?December?2022?were?selected?as?study?objects，?they?were?divided?into?routine?group，?control?group?and?observation?group?according?to?random?number?table?method，?with?30?cases?in?each?group.?Patients?in?routine?group?were?treated?with?memantine?hydrochloride?tablets，?patients?in?control?group?were?treated?with?music?therapy?on?the?basis?of?routine?group，?patients?in?observation?group?were?treated?with?repeated?transcranial?magnetic?stimulation?on?the?basis?of?routine?group，?and?they?were?all?treated?for?12?weeks.?BPSD?severity，?dementia?severity，?cognitive?function，?ability?of?daily?living?and?ApoE?gene?polymorphism?were?compared?among?the?three?groups.?Results?Before?treatment，?there?were?no?significant?differences?in?the?scores?of?neuropsychiatric?inventory?（NPI），?clinical?dementia?rating?（CDR），?mini-mental?state?examination?（MMSE）?and?activity?of?daily?living?（ADL）?scale?among?the?three?groups?（P0.05）.?After?treatment，?the?NPI?and?CDR?scores?of?three?groups?were?significantly?lower?than?before?treatment，?and?the?MMSE?and?ADL?scores?were?significantly?higher?than?before?treatment?（P0.05）.?The?scores?of?NPI?and?CDR?in?observation?group?and?control?group?were?significantly?lower?than?those?in?routine?group，?while?the?scores?of?MMSE?and?ADL?were?significantly?higher?than?those?in?routine?