聚乙二醇修饰氧化石墨烯复合材料负载替莫唑胺制剂的制备及其性能研究.pdfVIP

目录

中文摘要······························································································1

英文摘要······························································································3

英文缩写······························································································6

研究的论文

聚乙二醇修饰氧化石墨烯复合材料负载替莫唑胺制剂的制备及其性

能研究

前言·····························································································8

材料与方法·················································································10

结果···························································································19

附图···························································································30

附表···························································································44

讨论···························································································49

结论·································································································52

参考文献·····························································································53

综述功能化氧化石墨烯载药性能研究进展·······························62

致谢·································································································75

个人简历·····························································································76

聚乙二醇修饰氧化石墨烯复合材料负载替莫唑胺制剂的制备

及其性能研究

摘要

氧化石墨烯（Grapheneoxide,GO），是石墨烯的一种衍生物，其

连有一些羟基、羧基、环氧基等含氧官能团。它具有独特的二维结构，

亲水性和机械性能好，比表面能高，所以对很多化学物质都有良好的

吸附性，这些优点使GO成为理想的药物载体。随着对氧化石墨烯的

深入研究，人们相继用聚乙二醇（Polyethyleneglycol，PEG）、四氧化

三铁、叶酸等修饰GO，得到功能化的氧化石墨烯可以负载难溶药物，

并在水中形成具有良好分散性和缓释性的纳米悬浮溶液，靶向到肿瘤

部位，提高治疗效果。

脑胶质瘤是发生于中枢神经系统的一种恶性肿瘤，临床主要采用

手术后放疗和化疗的治疗方法。由于放疗对肿瘤细胞的残余病灶可能

造成再次复发，因此药物化疗作为胶质瘤