肾上腺皮质激素类药物习题与结构分析.pdfVIP

Chapter32Adrenalcorticosteroids

一、A

1.Whichofthefollowingstructuralformulasiscommonlyused

adrenalcorticosteroids?

A.

B.

C.

D.

E.

2.Inthechemicalstructureofhydrocortisonewithstronganti-infltoryeffects,wherecanthedoublebondbeintroducedatthe

positiontoenhancetheanti-infltoryeffectandreducethesideeffects?

A.C-5bit

B.C-7bit

C.C-11bit

D.C-1bit

E.C-15bit

3.Whichofthefollowingisthechemicalnameofmedroxyprogesteroneacetate

A.7β-hydroxy-androst-4-en-3-onepropionateB.17β-hydroxy-19-no-17α-

pregnant-4-en-20-yn-3-oneC.D(-)-17α-ethynyl-17β-hydroxy-18-methytrost-4-en-3-oneD.11β-

(4-dimethylaminophenyl)-17β-hydroxy-17α-propynyl-estrost-4,9-diene-3-one

E.6α-甲基-17α-羟基孕甾-4-烯-3，20-二酮-17-醋酸酯

【该题针对“肾上腺皮质激素类药物-单元测试”知识点进行考核】

4、以下哪个药物含有α-羟基酮结构，与碱性酒石酸铜作用生成氧化亚铜橙红色沉淀

A.苯丙酸诺龙

B.醋酸地塞

C.酮

D.雌二醇

E.达那唑

【该题针对“肾上腺皮质激素类药物-单元测试”知识点进行考核】

E.6α-methyl-17α-hydroxypregnant-4-ene-3,20-dione-17-acetate

[Thisquestionevaluatestheknowledgepointsofadrenalcorticosteroiddrugs-unittest]

4.Whichofthefollowingdrugscontainsα-hydroxyketonestructure,whichinteractswithalkalinecoppertartratetoform

copperoxideorange-redprecipitate

A.

Northopropionate

B.Dexamethasone

acetateC.

ProgesteroneD.

EstradiolE.

Danazole

[Thisquestionevaluatestheknowledgepointsofadrenalcorticosteroiddrugs-unittest]

5、易引起严重尿潴留，故而只能外用的药物是

A.

B.

C.

D.

E.

【该题针对“肾上腺皮质激素类药物-单元测试”知识点进行考核】

6、对糖皮质激素类的药物构效关系描述错误的是

A.21位羟基酯化可延长作用时间并增加稳定性

B.1，2位脱氢抗炎活性增大，钠潴留作用不变

C.C-9α位引入氟原子，抗炎作用增大，盐代谢作用不变

D.C-6α位引入氟原子，抗炎作用增大，钠潴留作用也增大

5.Itiseasytocausesevereadversereactionsinurinaryretention,sotheonly

externalmedicineis

A.

B.

C.

D.

E.

[Thisquestio