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4-Sulfocalix[4]arene

Cat.No.:HY-W440555

CASNo.:112269-92-8

Synonyms:para-Sulfonatocalix[n]arene

分⼦式:C₂₈H₂₄O₁₆S₄

分⼦量:744.74

作⽤靶点:Amyloid-β

作⽤通路:NeuronalSignaling

储存⽅式:RT,storedundernitrogen

*Insolvent:-80°C,6months;-20°C,1month(RT,stored

undernitrogen)

BIOLOGICALACTIVITY

⽣物活性4-Sulfocalix[4]arene(para-Sulfonatocalix[n]arene)是⼀种淀粉样蛋⽩-β42(amyloid-beta42)结合剂，其Kd

值为5.39M。4-Sulfocalix[4]arene能够抑制淀粉样β肽的纤维化并降低淀粉样蛋⽩的细胞毒性[1]。

REFERENCES

[1].WangZ,etal.para-Sulfonatocalix[n]arenesInhibitAmyloidβ-PeptideFibrillationandReduceAmyloidCytotoxicity.ChemAsianJ.2017

Feb1;12(3):341-346.

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