Desamino-lenalidomide-5-F-4-CH2NH2-hydrochloride-生命科学试剂-MCE.pdfVIP

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Desaminolenalidomide-5-F-4-CH2NH2hydrochloride

Cat.No.:HY-W871182

CASNo.:2924122-72-3

分⼦式:C₁₄H₁₅ClFN₃O₃

分⼦量:327.74

作⽤靶点:LigandsforE3Ligase

作⽤通路:PROTAC

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Desaminolenalidomide-5-F-4-CH2NH2hydrochloride是⼀种E3泛素连接酶cereblon(CRBN)配体，⽤于募

集cereblon蛋⽩。Desaminolenalidomide-5-F-4-CH2NH2hydrochloride可通过linker连接到靶蛋⽩配体上

形成PROTAC。

IC50TargetCereblon

体外研究PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaligandforanE3ubiquitinligaseand

theotherisforthetargetprotein.PROTACsexploittheintracellularubiquitin-proteasomesystemto

selectivelydegradetargetproteins.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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