抗寄生虫药Antiparasitedrugs-方三华.pptVIP

FangSanhua;Humanparasite;

Antimalarialdrugs;;5;Fourspeciesofplasmodiumcanproducethediseaseinitsvariousforms:

Plasmodiumfalciparum（恶性疟原虫）

Plasmodiumvivax（间日疟原虫）

Plasmodiumovale（卵形疟原虫）

Plasmodiummalaria（三日疟原虫）

;;Nooneavailableagentcanreliablyeffectaradicalcure,ie,eliminatebothexo-erythrocyticanderythrocyticstages.

Fewavailableagentsarecausalprophylacticdrugs,ie,capableofpreventingerythrocyticinfection.;;Antimalarialdrugs–Chloroquine（氯喹）;Pharmacologicaleffects

1.Antimalarialeffects

Rapidschizonticidalactivity（裂殖体杀灭剂）againstallinfectionsofmalariaspecies.

Alsogametocytocidal（杀配子体）againstP.vivax,P.malariaeandP.ovale.

Itisnotactiveagainstexo-erythrocyticform,andshouldthereforebeusedwithprimaquine（伯氨喹）toeffectradicalcureofP.vivax.;Antimalarialdrugs-Chloroquine;Antimalarialdrugs-Chloroquine;Antimalarialdrugs-Chloroquine;Quinine（奎宁）

Mefloquine（甲氟喹）

Pyronaridine(咯萘啶)

Artemisinin(青蒿素)

Artemetherandartesunate

(蒿甲醚和青蒿琥酯);;Antimalarialdrugs–Primaquine（伯氨喹）;Antimalarialdrugs–Primaquine（伯氨喹）;;Antimalarialdrugs–Pyrimethamine（乙胺嘧啶）;;;;;;

Antiamebiasisdrugs;Antiamebiasisdrugs-Amebiasis;;FeaturesofAmebiasis;MultiplicationandlifecycleofEhistolytica;Antiamebiasisdrugs-Amebiasis;Antiamebiasisdrugs-Metronidazole甲硝唑;Mechanismofactions

Themethylgroupofmetronidazoleischemicallyreducedinanaerobicbacteriaandsensitiveprotozoans.（原生动物）

Reactivereductionproductsappeartoberesponsibleforantimicrobialactivity.

Rapidlyabsorbedandhasabioavailabilityofapproximately90%

;;Emetine依米丁dehydroemetine去氢依米丁

Amebicideeffects:sporadin(滋养体)

Mechanismofactions:proteinsynthesisinhibitor.

Clinicuses:

Amebicliverabscess,Acuteamebicdysentery

Usedincaseofresistancetometronidazole.;Emetine依米丁dehydroemetine去氢依米丁

Adverseeffects

Nausea,vomitinganddiarrhoea.

Palpitations,tachycardia,retr