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Intoplicine(Standard)

Cat.No.:HY-101647R

CASNo.:125974-72-3

分⼦式:C₂₁H₂₄N₄O

分⼦量:348.44

作⽤靶点:Topoisomerase;ReferenceStandards

作⽤通路:CellCycle/DNADamage;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Intoplicine(Standard)是Intoplicine(HY-101647)的分析标准品。本产品⽤于研究及分析应⽤。Intoplicine

(RP60475)，⼀种7H苯并[e]吡啶并[4,3-b]吲哚系列的抗肿瘤衍⽣物，是⼀种DNA拓扑异构酶I和II抑制剂

。Intoplicine与DNA(KA=2x105/M)强烈结合，从⽽增加线性DNA的长度[1]

IC50TargetDNAtopoisomerase[1]

REFERENCES

[1].EckardtJR,etal.ActivityofIntoplicine(RP60475),anewDNAtopoisomeraseIandIIinhibitor,againsthumantumorcolony-forming

unitsinvitro.JNatlCancerInst.1994Jan5;86(1):30-3.

[2].MorjaniH,etal.MolecularandcellularinteractionsbetweenIntoplicine,DNA,andtopoisomeraseIIstudiedbysurface-enhanced

Ramanscatteringspectroscopy.CancerRes.1993Oct15;53(20):4784-90.

[3].BisseryMC,etal.Antitumoractivityofintoplicine(RP60475,NSC645008),anewbenzo-pyrido-indo