ME-3407-EF-4040-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

ME3407

Cat.No.:HY-19133

CASNo.:133903-90-9

Synonyms:EF-4040

分⼦式:C₁₂H₁₄N₂O₃S₂

分⼦量:298.38

作⽤靶点:Na+/K+ATPase;Myosin;PKA

作⽤通路:MembraneTransporter/IonChannel;Cytoskeleton;Stem

Cell/Wnt;TGF-beta/Smad

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性ME-3407(EF-4040)是⼀种H+-K+-ATPase重新分布抑制剂以及肌球蛋⽩轻链激酶(MLCK)和蛋⽩激酶A

(proteinkinaseA)抑制剂。ME-3407能够通过抑制微粒体⾄顶端膜H+-K+-ATPase的重新分布以及抑制

MLCK介导的肌球蛋⽩轻链磷酸化来阻断胃酸分泌和氨基吡啶的积累。ME-3407有望⽤于胃溃疡的研究。

IC50TargetMLCK

REFERENCES

[1].UrushidaniT,etal.ME-3407,anewantiulceragent,inhibitsacidsecretionbyinterferingwithredistributionofH(+)-K(+)-ATPase.AmJ

Physiol.1997May;272(5Pt1):G1122-34.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Tel:400-820-3792;021Fax:021E-mail:tech@MedChemE