MDI-403-生命科学试剂-MCE.pdfVIP

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MDI-403

Cat.No.:HY-W816575

CASNo.:127471-94-7

分⼦式:C₂₉H₃₆O₄

分⼦量:448.59

作⽤靶点:RAR/RXR;SARS-CoV

作⽤通路:MetabolicEnzyme/Protease;VitaminDRelated/Nuclear

Receptor;Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性MDI-403是⼀种视黄酸受体(RAR)激动剂，其EC501μM。MDI-403对SARS-CoV-2具有显著抗病毒活性

，可剂量依赖性地抑制病毒核蛋⽩(NP)表达，降低感染细胞⽐例。MDI-403主要作⽤于病毒⼊侵阶段。MDI-

403可⽤于抗SARS-CoV-2研究。

REFERENCES

[1].RivaL,etal.DiscoveryofSARS-CoV-2antiviraldrugsthroughlarge-scalecompoundrepurposing.Nature.2020Oct1;586(7827):113-9.

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