MEDI4276-生命科学试剂-MCE.pdfVIP

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MEDI4276

Cat.No.:HY-177710

作⽤靶点:Antibody-DrugConjugates(ADCs);EGFR

作⽤通路:Antibody-drugConjugate/ADCRelated;JAK/STATSignaling;

ProteinTyrosineKinase/RTK

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性MEDI4276是⼀种双表位四价抗体，靶向HER2胞外域2和4亚域中两个不重叠的表位。MEDI4276由

MEDI4276Antibody(HY-P991238)和细胞毒性载荷AZ1508(HY-128962)通过位点特异性偶联组成。

MEDI4276具有抗肿瘤活性[1]。

IC50TargetHER2

REFERENCES

[1].PegramMD,etal.First-in-Human,Phase1Dose-EscalationStudyofBiparatopicAnti-HER2Antibody-DrugConjugateMEDI4276in

PatientswithHER2-positiveAdvancedBreastorGastricCancer.MolCancerTher.2021Aug;20(8):1442-1453.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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