M4K-2009-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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M4K-2009

Cat.No.:HY-149591

CASNo.:2600795-07-9

分⼦式:C₂₅H₂₉N₃O₃

分⼦量:419.52

作⽤靶点:TGF-βReceptor

作⽤通路:TGF-beta/Smad

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性M4K-2009是⼀种可穿透⾎脑屏障的ALK2抑制剂，IC50为13nM。M4K-2009是LDN-214117(HY-16712)的

类似物。M4K-2009也对hERG钾通道有活性[1][2][3]。

REFERENCES

[1].González-Álvarez,H.,etal.,(2024).DiscoveryofConformationallyConstrainedALK2Inhibitors.Journalofmedicinalchemistry,67(6),

4707-4725.

[2].Ensan,D.,(2020).TargetingALK2:AnOpenScienceApproachtoDevelopingTherapeuticsfortheTreatmentofDiffuseIntrinsic

PontineGlioma.Journalofmedicinalchemistry,63(9),4978-4996.

[3].Smil,D.,(2020).LeveraginganOpenScienceDrugDiscoveryModeltoDevelopCNS-PenetrantALK2InhibitorsfortheTreatmentof

DiffuseIntrinsicPontineGlioma.Journalofmedicinalchemistry,63(17),10061-10085.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.