Necrosulfonamide-Standard-生命科学试剂-MCE.pdfVIP

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Necrosulfonamide(Standard)

Cat.No.:HY-100573R

CASNo.:1360614-48-7

分⼦式:C₁₈H₁₅N₅O₆S₂

分⼦量:461.47

作⽤靶点:MixedLineageKinase;ReferenceStandards;Necroptosis;

Pyroptosis;Caspase;NOD-likeReceptor(NLR);Keap1-Nrf2;

TNFReceptor;InterleukinRelated;NOSynthase;Heme

Oxygenase(HO)

作⽤通路:MAPK/ERKPathway;Others;Apoptosis;

Immunology/Inflammation;NF-κB;MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Necrosulfonamide(Standard)是Necrosulfonamide(HY-100573)的分析标准品。本产品⽤于研究及分析应⽤

。Necrosulfonamide是⼀种MLKL和GasderminD(GSDMD)的抑制剂，能够分别抑制细胞的坏死性凋亡(

necroptosis)和焦亡(pyroptosis)。Necrosulfonamide不影响上游信号的激活，是特异地抑制下游的执⾏器寡

聚化步骤。Nec

REFERENCES

[1].SunL,etal.Mixedlineagekinasedomain-likeproteinmediatesnecrosissignalingdownstreamofRIP3kinase.Cell.2012;148(1-2):213-

227.

[2].YangW,etal.NecrosulfonamideamelioratesintestinalinflammationviainhibitingGSDMD-medicatedpyroptosisandMLKL-mediated

necroptosis.BiochemPharmacol.2022Dec;206:115338.

[3].ZhouXY,etal.ThebrainprotectionofMLKLinhibitornecrosulfonamideagainstfocalischemia/reperfusion