25年生物信息学研究历程与成果概览.pptx

My25YearsinCSIRandinBioinformatics

GPSRaghavaInstituteofMicrobialTechnologySector39A,Chandigrah,IndiaEmail:Raghava@imtech.res.in Web:http://www.imtech.res.in/raghava/ /

My25YearsinBioinformaticsIMTECHisoneoforiginalDIC’sstartedbyDBTIstartmycarrierin1986ascomputerscientistMyfirsttaskwastosupportDICatIMTECH1986-91:Infrastructure(Email,NICNET,Medline)1991-1996:Serviceswithdevelopmentofcomputerprograms1996-2001:Databaseddiscovery,proteinstructure,web2001-2006:Drug/Vaccinetargetsandgenomeannotation2006-2011:Integrationoftoolscollaboration2011-2016?:Drug/Vaccineinreallife

1986-91:InfrastructureServicesLiteraturesearchDIALOGsearchviaTelexMicroVaxII(Firstpowerfulcomputer)NucleotideandSequencedataontapesNICNETconnectivityanddatabasessearchesEmail-FacilityviaERNET(UUCP)EmailviaNICNETtootherDICsEMBLdataandsoftwareviaEmailServers

1991-1996:AdvancelevelofserviceSoftwaredevelopmentforbiologicalproblemsFirstresearchpublication(1991)NumberofpublicationsEstablishmentofINTERNETCompletedPh.D.(1996)

1996-2001:InternationalPresenceMethodsdevelopedforproteinstructurepredictionParticipatedinInternationalcompetitionCASPWorkedatOxfordUniversity,UK(1996-1998)Mirror-SitesofsoftwarearchievesWebbasedapplicationslaunched

2001-2006:Drug/VaccinetargetsandgenomeannotationAdaptiveImmunity(CellularResponse):ThelperEpitopesAdaptiveImmunity(CellularResponse):CTLEpitopesAdaptiveImmunity(HumoralResponse):B-cellEpitopesInnateImmunity:PathogenRecognizingReceptorsandligandsSignaltransductioninImmuneSystemPropred:forpromiscuousMHCIIbindersMMBpred:forhighaffinitymutatedbindersMHC2pred:SVMbasedmethodMHCBN:AdatabaseofMHC/TAPbindersandnon-bindersPcleavage:forproteomecleavagesitesTAPpred:forpredictingTAPbindersPropred1:forpromiscuousMHCIbindersCTLpred:PredictionofCTLepitopesCytopred:forc