SEN-78702-生命科学试剂-MCE.pdfVIP

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SEN78702

Cat.No.:HY-18176

CASNo.:1205530-63-7

分⼦式:C₁₇H₂₂FN₅O

分⼦量:331.39

作⽤靶点:nAChR;PotassiumChannel

作⽤通路:MembraneTransporter/IonChannel;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性SEN78702是⼀种⼝服活性、选择性的完全α7nAChR激动剂，pEC50为6.13。SEN78702具有可接受的

hERG抑制作⽤(IC50:15.8μM)。SEN78702可增强记忆⼒。

IC50TargetpEC50:6.13(α7nAChR);IC50:15.8μM(hERG)[1]

REFERENCES

[1].ZanalettiR,etal.N-[5-(5-Fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide(SEN78702,WYE-308775):AMedicinal

ChemistryEfforttowardanα7NicotinicAcetylcholineReceptorAgonistPreclinicalCandidate[J].JournalofMedicinalChemistry,2012,

55(22):10277-10281.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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