细胞信号转导课件.pptVIP

HeterotrimericProtein:Gα,GβandGγGα:27,Gβ:6,Gγ:14Gproteinno:27×6×14=2268GαhasGTPaseactivity,GβandGγFormsheterodimerGβγEffectorsGβγGαAdenylylcyclaseIonchannelsAdenylylcyclasePLCIonchannelsProposedmodelofG-proteinmediatedsignalingRegulatorsofG-ProteinSignalingproteins(RGS)Discovery:Geneticstudiesofyeast,wormsandAspergillusRolesofRGSproteinsinG-proteinsignaling:(1)Gαactivatingprotein(GAP)(2)RGSproteinsinteractwithothereffectors2、細胞信號轉導分為三個階段（時期）：感受（Perception）:即靶細胞（targetcell）對來