安徽省立医院 - 甲状腺疾病的实验室检查.pptVIP

* T4 Disposition. In healthy individuals, about 41% of T4 is converted to T3, about 38% is converted to reverse T3 (rT3), and about 21% is metabolized via other pathways, such as conjugation in the liver and excretion in the bile. Reverse T3, which is metabolically inactive, results from removal of the iodine on position 5 of the inner ring. The normal circulating concentration of T4 is 4.5-11 ?g/dL. The normal circulation concentration of T3 is about 100-fold less (60-180 ng/dL).1 Reference 1. Hardman JG, Limbird LE, eds. Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 9th ed.