血浆TNF-α与大动脉炎的相关性研究.docVIP

  血浆 TNF-α与大动脉炎的相关性研究# 党爱民，吕纳强，高倩，成艳美，王志广，刘国仗，郑德裕* （中国医学科学院，北京协和医学院，阜外心血管病医院心内科） 5 摘要：研究目的 血浆肿瘤坏死因子（TNF-α ）浓度与大动脉炎病情进展的关联。 方法 采 用病例对照研究设计，共 75 例汉族大动脉炎患者和 45 例健康对照者入选，通过分析 TNF- α 血浆浓度与大动脉炎患者的病情进展、分期的关系，探讨 TNF-α 对大动脉炎病情的影响。 结果 活动期大动脉炎患者血浆 TNF-α 明显高于静止期大动脉炎患者（25.17 pg/mL vs 10 15 20 25 30 35 40 10.79 pg/mL， P0.01）与健康对照组（25.17 pg/mL vs 11.74 pg/mL，P0.01）。结论 在 中国汉族大动脉炎患者中血浆 TNF-α 浓度与大动脉炎活动性相关。 关键词：大动脉炎；肿瘤坏死因子α ；活动期 中图分类号：R543.1 The association between plasma concentrations of TNF-α with Takayasu arteritis Dang Aimin, Lv Naqiang, Gao Qian, Cheng Yanmei, Wang Zhiguang, Liu Guozhang, Zheng Deyu (Department of Cardiology, FuWai Hospital, CAMS PUMC, Beijing 100037, China) Abstract: To explore the association between plasma concentrations of tumor necrosis factor-α (TNF-α) with the pathogenesis of Takayasu arteritis (TA) in Chinese Han population. Methods: A case-control study was carried out to investigate the relationship between plasma concentrations of TNF-α and takayasu arteritis. A total of 75 unrelated patients with Takayasu arteritis and 45 healthy controls in Chinese Hans were included in this study. Plasma concentrations of TNF-α were determined by ELISA. Results: The active patients had significantly increased TNF-α plasma levels (n = 30, 25.17 pg/mL, 25th–75th percentiles, 9.54–38.36 pg/mL) compared with the remission patients (n = 45, 10.79 pg/mL, 25th–75th percentiles, 7.65–27.78 pg/mL) and controls (n = 45, 11.74 pg/mL, 25th–75th percentiles, 8.04–16.48 pg/mL). Conclusion: The TNF-α plasma levels were significantly increased in active patients of Takayasu arteritis in Chinese Han population. Key words: Takayasu arteritis; TNF-α; Active stage 0 引言 大动脉炎(Takayasu arteritis, TA) (Takayasu arteritis, TA) 是一种累及主动脉及其主要分 支的慢性进行性非特异性血管炎性疾病，常表现为全身炎性反应及其受累脏器缺血症状[1]。 的病情进展表现为活动期与静止期交替，活动期血管炎症进展快，促炎细胞因子介导的炎症 反应活跃。肿瘤坏死因子? (Tumor necrosis factor-?，TNF-?)是人体内主要的致炎细胞因子 之一，广泛参与体内的炎性过程，除自身免疫杀伤作用外，尚可通过调节多个细胞因子的免 疫应答强度，介导血管细胞的炎症反应，与血管炎症性疾病的发生、发展密切相关[2-3]，本 研究通过检测大动脉炎患者体内