半乳糖修饰聚己内酯的制备和表征.docVIP

  半乳糖修饰聚己内酯的制备和表征# 张琰，张一* （华东理工大学材料科学与工程学院 上海 200237） 5 10 15 20 25 30 35 40 摘要：材料的表面性质不仅能影响细胞的吸附和增殖，并且会影响细胞的分化，最终可控制 组织的生成。聚己内酯（PCL）具有良好的生物相容性和生物降解性，以及优良的机械性能 和可加工性，因此，受到了广泛关注。但是亲水性差，缺乏可反应性官能团和生物活性分子 等表面性质，导致了材料与细胞间相互作用弱，使其在组织工程领域中的应用受到了限制。 因此，聚己内酯的表面改性来提高其长期生物相容性已成为其在组织工程领域中应用的热 点。以乳糖酸和氨基修饰的聚己内酯为原料，在 l-乙基-3(3-二甲氨丙基)碳二亚胺盐酸盐和 N-羟基琥珀酰亚胺缩合剂的催化作用下合成了侧链带半乳糖的聚己内酯（GPCL）。核磁、 红外光谱和凝胶渗透色谱法表征了聚合物的结构和分子量并确证了乳糖酸分子偶联成功，广 角 X 射线衍射和差示扫描量热法表征了聚合物的结晶性和热力学性能。研究用文语句重复。 关键词：表面修饰；聚己内酯；半乳糖关键 中图分类号：O63 Preparation and characterization of galactose decorated poly（ε-caprolactone） ZHANG Yan, ZHANG Yi (School of Materials Science and Technology,East China Univeristy of Science and Technology Shanghai 200237) Abstract: Surface physiochemical properties of biomaterials can not only affect cell adhesion and proliferation, But also their differentiation capacity and, ultimately, the quality of new tissue formation. Poly(ε-caprolactone) (PCL) has been intensively investigated in recent years due to its good biocompatibility and biodegradability, as well as its excellent mechanical properties and machinability. However, because of its intrinsic hydrophobic and laking of bioactive functional groups on the main chain, the interactions between cells and PCL materials were hindered, which result in a limited application as tissue engineering scaffolds. Therefore, Surface modification of PCL has now became a hot way to improve its long-term biocompatibility in tissue engineering.Using lactobionic acid (LA) and NPCL as raw material, 1-Ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC) and N-hydroxysulfosuccinimide (NHS) as crosslinking agent to synthesis a new galactosylated poly(ε-caprolactone) (GPCL) with pendant galactose residues. The structures of polymers were characterized by 1H NMR, FT-IR, GPC, and proved the lactobionic molecules have been successfully coupled onto NPCL. The crystallinity and thermal properties of GPCL were studied by WAXD and DSC. Key words: surface modificatio