采用超声心动图和组织多普勒显像评估肥厚型心肌病左室舒张功能与血浆脑钠肽前体的相关性.docVIP

采用超声心动图和组织多普勒显像评估肥厚型心肌病左室舒张功能与 血浆脑钠肽前体的相关性☆ 沃金善1，赵 青1，郭 洁1，李 波2 Correlation of left ventricular diastolic function to plasma N-terminal pro-brain natriuretic peptide in patients with hypertrophic cardiomyopathy detected by echocardiogram and tissue Doppler imaging Wo Jin-shan1, Zhao Qing1, Guo Jie1, Li Bo2 Abstract AIM: To investigate the relationship between N-terminal pro-brain natriuretic peptide (NT-proBNP) and left ventricular diastolic function of hypertrophic cardiomyopathy (HCM) patients. METHODS: ①Sixty-three HCM patients, including 17 hypertrophic obstructive cardiomyopathy (HOCM) and 46 hypertrophic non-obstructive cardiomyopathy (HNCM), admitted in the Affiliated Hospital of Qingdao University Medical College between February 2006 and August 2007, and 20 healthy testees as normal control were enrolled in this study.②All the subjects were studied via electrochemical radiation to test NT-proBNP levels; Echocardiogram and tissue Doppler imaging were applied to detect thickness of interventricular septum, ejection fraction, pressure gradient of left ventricular outflow tract, and the parameters to reflect left ventricular diastolic function; the correlation of NT-proBNP levels and the diastolic function detected by echocardiogram was also analyzed. RESULTS: ①The plasma NT-proBNP concentration in the HCM group was higher than that in the control group (P 0.000 1), higher in HOCM patients than in HNCM patients (P =0.016). The NT-proBNP concentration was positive related with the pressure gradient of left ventricular outflow tract (r =0.42, P =0.016).②The plasma NT-proBNP concentration have a positive correlation with the multi-parameters of left ventricular diastolic function via echocardiogram (P 0.05); Multi-factor Logistic regression analysis showed that the early/late diastolic peak velocity ratio of mitral ventricular septum, and the diastolic-systolic velocity ratio of pulmonary venous flow pattern were the independent influenced factors of NT-pro