不同膳食纤维对重型颅脑损伤患者肠屏障的影响.docVIP

不同膳食纤维对重型颅脑损伤患者肠屏障的影响 摘要 目的：探讨不同膳食纤维对严重颅脑损伤患者肠屏障保护作用。方法：颅内损伤患者肠内营养给予能全素（不含膳食纤维）、能全力、复合膳食纤维，检测血浆中内毒素(LPS)、二胺氧化酶(DAO)、D-乳酸含量，并评价在入院时、入院后14天、28天GCS评分，进行比较分析。结果：在入院或手术后1天，能全素组、能全力组、复合膳食纤维组LPS、DAO、D-乳酸水平无统计学差异，在7d后，与能全素组相比，能全力治疗组和复合膳食纤维组LPS、DAO、D-乳酸水平在7天和14天明显降低，其中复合纤维素组降低更明显。在入院或手术后1天，能全素组、能全力组、复合膳食纤维组GCS评分无统计学差异，但在7d后，与能全素组相比，能全力治疗组和复合膳食纤维组GCS评分在7天和14天明显增高，其中复合纤维素组GCS评分增高更明显。结论：在重型颅脑损伤病人中，给予含有膳食纤维的场内营养对肠屏障具有明显的保护作用，但以给予复合膳食纤维保护作用最为明显调节肠道功能，对病人病情的恢复具有明显的保护作用。 The Protective Effects of Different Dietary Fiber on Intestinal Barrier in Patients with Severe Traumatic Brain Injury Abstract Objective: To investigate the protective effect of different dietary fiber on intestinal barrier in patients with severe traumatic brain injury. Methods: Enteral nutrition in patients with intracranial injury was given with Nutrison (excluding dietary fiber), Nutrison fiber, and complex dietary fiber. Detection plasma endotoxin (LPS), diamine oxidase (DAO), D-lactic acid content, and evaluation of admission, 14 days after admission, and 28 days GCS score to conduct a comparative analysis. Results: The study showed that 1 day after admission or surgery, LPS, DAO, D-lactate levels had no statistical differences of three groups. 7d after compared with the Nutrison group, the plasma LPS, DAO, D-lactate levels in 7 days and 14 days significantly reduced in Nutrison fiber and complex dietary fiber treated group, which reduce the complex cellulose group is more obvious. At 1 day after admission or surgery, GCS score had no significant difference among three groups, but, after 7d, compared with the Nutrison group, GCS score in 7 days and 14 days was significantly higher in Nutrison fiber and complex dietary fiber treated group, in which complex dietary fiber treated group GCS score increased more obvious. Conclusion: In patients with severe brain injury, giving the floor containing the dietary fiber nutrition on intestinal barrier in significant exert protective effect, but complex fiber exert the