SNCA基因在酒精依赖遗传机制中的研究进展.pdfVIP

HEREDITAS (Beijing) 2010 11 , 32(11): 1114―1118 ISSN 0253-9772 综述 DOI: 10.3724/SP.J.1005.2010.01114 SNCA基因在酒精依赖遗传机制中的研究进展 1, 2 1 杨永强 , 李凡 1. , 471003; 2. , 461000 SNCA 基因定位于酒精依赖数量性状位点之上, 其编码的蛋白—α-synuclein 可以在多个水平上调节多 巴胺的功能, 而后者是酒精依赖中重要的神经递质。研究还发现酒精依赖者SNCA 基因存在多处基因变异, 同 时, 酒精依赖者 SNCA 基因的表达水平也存在显著增高, 并且增高的程度与酒精依赖程度密切相关, 因此, SNCA 基因被认为参与酒精依赖的遗传机制。文章对 SNCA 基因与多巴胺的关系和酒精依赖者 SNCA 基因变 异以及基因表达的研究进展做一综述。 SNCA基因; 多巴胺; 酒精依赖; 遗传机制 Inheritance machnisam of gene SNCA for alcohol dependence YANG Yong-Qiang 1, 2, LI Fan1 1. Department of Forensic Medicine, Henan University of ScienceTechnology, Luoyang 471003, China; 2. Hospital Teaching Office, Xuchang Central Hospital, Xuchang 461000, China Abstract: SNCA gene is located in a quantitative trait locus for alcohol preference. α-synuclein coded by SNCA gene can regulate the function of dopamine in multiple levels, and dopamine is an important neurotransmitter in alcohol preference. Variation has been found in SNCA gene carried by alcohol-dependent patients. Meanwhile, significant increase of SNCA gene expression also occurs in alcohol-dependent patients, which is closely associated with the level of alcohol dependence. Therefore, SNCA gene is believed to contribute to genetic mechanism of alcohol dependence. Here, the relationship be- tween SNCA gene and dopamine, the variation and expression of SNCA gene in alcohol-dependent patients were reviewed. Keywords: SNCA gene; dopamine; alcohol dependence; genetic mechanism clein (α-syn)(Dopamine, DA) , , DA[3] , DA, , , SNCA