Chapter 2 - Innate Immunity - Part 1课件.pptVIP

* * * * * * * * * * Natural Killer Cell Respond to intracellular microbes by killing the infected or stressed cell and producing the macrophage activating cytokine – INF? ~10% total lymphocytes in blood and peripheral lymphoid tissues Contain cytoplasmic granules and surface markers but no immunoglobulins or T-cell receptors Recognize altered host cells virally infected host cells or phagocytes with viruses or intracellular bacteria Activation releases granulaes toward infected cell, proteins enter cell and initiate apoptosis similar activities of CTL to kill infected cells (Chapter 6) NK Cell