埃索美拉唑与兰索拉唑治疗反流性食管炎的疗效比较.pdfVIP

埃索美拉唑与兰索拉唑治疗反流性食管炎的疗效比较 马晓鹂 ，周 宇，魏国丽 (1．广东医学院附属医院药学部，湛江市 524001；2．广东医学院附属医院消化 科，湛江市 524001) 中图分类号 R969．4；R975 ．2 文献标识码 A 文章编号 2009)35—2764—03 摘 要 目的：比较埃索美拉唑与兰索拉唑治疗反流性食管炎的疗效。方法：120例反流性食管炎患者随机分为治疗组与观察组， 分别给予埃索美拉唑(20mg，早、晚餐前各 1次)、兰索拉唑(30mg，早、晚餐前各 1次)治疗 8周，在治疗后 4周和 8周通过症状(烧 心、胸痛、反酸)积分和 胃镜检查结果判断疗效。结果：治疗后 4周、8周，治疗组的临床症状总有效率分别为 78．1％、87．5％，胃镜检 查总有效率分别为87．5％、93．8％；观察组的临床症状总有效率分别为60．7％、73．2％，胃镜检查总有效率分别为73．2％、8O．4％； 2组总有效率比较差异均有统计学意义(P0．05)。结论：埃索美拉唑治疗反流性食管炎的疗效优于兰索拉唑。 关键词 埃索美拉唑；兰索拉唑；反流性食管炎 EsomeprazoleversusLansoprazolein theTreatmentofRefluxEsophagitis MAXiao—li(Dept．ofPharmacy，TheAffiliatedHospitalofGuangdongMedicalCollege，Zhanjiang524001， China) ZHOU Yu，WEIGuo—li(Dept．ofGastroenterology，TheAffiliatedHospitalofGuangdongMedicalCollege， Zhanjiang524001，China) ABSTRACT 0BJECTIVE：ToevaluatetheefficacyofesomeprazoleVS．1ansoprazoleinthetreatmentofpatientswithreflux esophagitis(RE)．METH0DS：Atotalof120patientswithREwererandomlyassignedtOreceiveeitheresomeprazole(20mg nm，treatmentgroup)orlansoprazole (30mgnm，controlgroup)for8weeks．Thesymptomaticscoresincludingheart— burn，retrosternalpainandacidregurgitation，andgastroscopiccurativeefficacyat4and8weekswereobtainedfortheeval— uation ofclinicalefficacy．RESULTS：Inthetreatmentgroup at4and8weeksaftertreatment，thetota1effectiveratesin improvementofclinicalsymptomswere78．1％ and87．5％，respectively，andthetotaleffectiveratesofgastroscopiccurative efficacywere87．5％ and93．8％ ，respectively；whileinthecontroIgroupat4and8weeks，thetotaleffectiveratesin im— provementofclinica1symptomswere60．7％ and 73．2％ ．respectively．and thetotaleffectiveratesin gastroscopiccurative efficacywere73．2％ and80．4％，respectively．showingstatisticaldifferencesintotaleffectiveratesbetweenesomeprazoleand lansoprazole(P0．05)．CONCLUSION：EsomeprazoleiSmoreeffectivethan1ansoprazoleinthetreatmentofRE． KEY W oRDS Esomeprazole；Lansoprazole；Refluxesophagitis 治疗反流性食管炎 (RE)的有效性依赖于抗酸分泌药 24h 收集我院2005年 6