叶酸修饰乳酸-羟基乙酸共聚物纳米粒的制备及性能表征.pdfVIP

中国组织工程研究与临床康复 第 12 卷 第 36 期 2008 –09 –02 出版 Journal of Clinical Rehabilitative Tissue Engineering Research September 2, 2008 Vol.12, No.36 基础实验 叶酸修饰乳酸-羟基乙酸共聚物纳米粒的制备及性能表征*★ 1 1 2 2 凌 友 ，黄岳山 ，梁常艳 ，李小毛 Preparation and characterization of folate-mediated poly (lactic-co-glycolic) acid nanoparticles 1 1 2 2 Ling You , Huang Yue-shan , Liang Chang-yan , Li Xiao-mao Abstract: Folate-mediated poly (lactic-co-glycolic) acid was prepared by the reaction of the activated folate ester and activated 1College of polymer with the amine group on the poly (ethylene glycol)-bis-amine. Folate-mediated poly (lactic-co-glycolic) acid Bioscience and Bioengineering, nanoparticles were then formulated with the emulsion-solvent evaporation method. Results of ultraviolet spectra (UV) spectrum South China test, infrared (IR) spectrum test and nuclear magnetic resonance (H 1NMR) test that the folate was conjugated successfully with University of polymer. The average diameter of nanoparticles was (276±12) nm and the Folate-mediated poly (lactic-co-glycolic) acid Technology, Guangzhou nanoparticles were spherical in shape as shown under the scanning election microscope. Folate-mediated poly (lactic-co-glycolic) 510006, Guangdong acid nanoparticles for loading paclitaxel could be prepared successfully with the method. Province, China; 2Department of Ling Y, Huang YS, Liang CY, Li XM.Preparation and characterization of folate-mediated poly (lactic-co-glycolic) aci