应用DNA免疫吸附器治疗系统性红斑狼疮观察.pdfVIP

应用DNA免疫吸附器治疗系统性红斑狼疮的观察 汤颖 娄探奇 陈珠江 王成 刘迅 【摘要】目的 观察DNA 免疫吸附器治疗系统性红斑狼疮 (systemic lupus erythematosus，SLE)的效果。方法 选取30例系统性红斑狼疮患者，运用DNA免疫吸附器治 疗，检测吸附治疗前后抗核抗体(ANA)、抗双链DNA抗体(ds-DNA)、IgA、IgG、IgM的抗体滴 度变化、补体C 、C 、血常规、电解质、肾功能、肝功能等指标并行统计学分析。结果 免疫 3 4 吸附治疗后，患者ANA、ds-DNA抗体滴度明显减少(P0.05)；血常规及其他各项生化指标无 明显改变，无肝肾功能损害(P0.05)，临床症状有不同程度的缓解。结论 DNA免疫吸附器对 系统性红斑狼疮治疗有效，能减少ANA、ds-DNA滴度水平，并且安全、无明显副反应。 【关键词】DNA免疫吸附器；免疫吸附；系统性红斑狼疮；抗核抗体(ANA)；抗双链DNA 抗体(ds-DNA) 中图分类号：R459.5 文献标识码：A The clinical observation of DNA immunoadsorbent on 3 systemic lupus erythematosus TANG Ying, LOU Tanqi, CHEN Zhujiang, et al.Department of Nephrology, The Third Affiliated Hospital of SUN Yat-sen University, Guangzhou 510630, China. [Abstract] Objective To observe Clinical effect of DNA immunoadsorbent on systemic lupus erythematosus(SLE)patients. Methods Strictly according to the standard of inclusion and exclusion，selecting 30 patients with SLE patients to accept immunoadsorption therapy and detect the titres of ANA and ds-DNA in pre-treatment and after-treatment Moreover the concentrations of ， ， IgA IgG IgM antibody C3 C4 and the change of blood routine electrolyte renal function 、 ， 、 、 ， 、 、 hepatic function ，then analyzed results by statistics ，P0.05 was considered as significant difference Results the titres of ANA and ds-DNA decreased after treatment which was significant ． difference compared with pretreatment (P0.05) ：the parameters of blood routine ，biochemical indicator remained static without obvious 1iver and nephron function loss ．The c1inical symptoms were improved Conclusion DNA immunoadsorbent has definitely better therapeutic effect which ． can exclusively decrease the levels of ANA ds-