AMPK在转化医学研究中的意义与展望.pdfVIP

中国细胞生物学学报 Chinese Journal of Cell Biology 2013, 35(3): 357–366 http ://www.cj AMPK在转化医学研究中的意义与展望 1* 焌 2 杨子初 廖 伶 1 ( 昆明医科大学第二附属医院胸心血管外科, 昆明650101; 2 昆明医科大学第二附属医院生殖生育中心, 昆明650101) 摘要 单磷酸腺苷活化蛋白激酶(AMPK)是一个调控能量稳态的重要激酶, 也是一个参与许 多细胞信号传导通路的关键蛋白。目前认为, AMPK不仅在代谢障碍而且在心血管疾病及生殖障 碍等许多病理状态中都具有重要的调节作用。此外, 它在人类恶性肿瘤中也扮演着重要的角色。 然而, 有关AMPK在临床上的作用及其重要意义尚未完全阐明。该文从分子生物学基础到临床应 用等多个方面详细综述了AMPK的研究进展, 指出AMPK是转化医学研究的热点, 围绕AMPK的研 究及其结果将作为未来多种疾病的分子治疗手段应用于个体化医疗中。 关键词 单磷酸腺苷活化蛋白激酶; 癌症; 心血管疾病; 细胞信号; 代谢障碍; 个体化医疗; 生 殖障碍; 转化医学 Implication and Prospect of AMPK in Translational Medical Research 1 2 Yang Zichu *, Liao Junling 1 ( Department of Thoracic and Cardiovascular Surgery, the Second Affiliated Hospital, Kunming Medical University, Kunming 650101, 2 China; Center for Reproduction and Fertility, the Second Affiliated Hospital, Kunming Medical University, Kunming 650101, China) Abstract 5′-Adenosine monophosphate-activated protein kinase (AMPK) is an important en- zyme in energy homeostasis. It is also a pivotal protein involved in many cellular signaling cascades. It is now considered as a key regulator not only in metabolic disorders but also in many other pathological conditions including cardiovascular disease and reproductive disorders. In addition, it plays a significant role in human malig- nancy. However, the property of AMPK in terms of clinical significance is not yet fully characterised. In this review, we covered current advances in AMPK research from the molecular basis to its clinical relev