ACA、AsAb与不孕及反复自然流产的关系.pdfVIP

Med＆PharmJChinPLA (OriginalTitle：MedJNatDefendingForcesinNorthChina)，Vo1．23，No．3，Jun．2011 ACA、AsAb与不孕及反复自然流产的关系 王红娟，刘学军，尹晓普，吴艳霞，崔丽华，张 伟 [摘要] 目的 探讨抗心磷脂抗体 (ACA)、抗精子抗体 (AsAb)与不孕、反复自然流产的关系。方法 采用酶联免疫吸 附法 (ELISA)对 124例不孕患者 (不孕组)、182例反复 自然流产(流产组)及 68例无流产史且已分娩的健康妇女 (对照组)血 清 ACA及AsAb进行测定分析并 比较。结果 不孕组 ACA阳性率为45．16％，AsAb阳性率为33．o6％，均显著高于对照组 (P0．O1)；流产组 ACA总阳性率为48．9o％，AsAb阳性率为26．92％，均显著高于对照组 (P0．01)。结论 妇女不孕及反 复 自然流产与体 内ACA和AsAb的存在有关。 【关键词] 流产，习惯性；不育，女(雌)性 ；抗心磷脂抗体 ；抗精子抗体 [中国图书资料分类号] R711．6；R714．2 [文献标志码] A [文章编号] 2095—140X(2011)03-0038—02 RelationshipbetweenAntieardiolipinAntibody，Antisperm Antibody，InfertilityandRecurrentSpontaneousAbortion WANGHong·juan，LIUXue—jun，YINXiao—pu，wUYah—xia3，CUILi—hua‘，ZHANGWei(1．DepartmentofObstetrics andGynecology，the256”‘ClinicalDepartmentofBethuneInternationalPeaceHospitalofPLA Zhengding，Hebei050800， ， China；2．DepartmentofObstetrics，theSecondAffiliatedHospitalofHebeiMedicalUniversity，Shijiazhuang050000，China； 3．DepartmentofObstetricsandGynecology，BethuneInternationalPeaceHospitalofPLA，Shijiazhuang050082，China) [Abstract] Objective Tostudytherelationshipbetweeninfertility，recurrentspontaneousabortion，anticardiolipin antibody(ACA)andantispermantibody(AsAb)．Methods SerumACAandAsAbin124patientswithinfertility(infertility group)，182patientswithrecurrentspontaneousabortion(abortiongroup)and68patientswithnormalwomen(controlgroup) weredetectedbyELISA．Results Thepositiveratesofserum ACA andtotalAsAb in infertilitygroup were45．16％ and 33．06％ respectively，significantlyhigherthanthoseincontrolgroup(P0．01)．ThepositiveratesofseurmACA andtotal AsAbinabortiongroupwere48．90％ and26．92％ respectively。significantlyhigherthanthoseinthecontrolgroup(P 0．01)．Conclusion TheprocessofinfertilityandreeurrentspontaneousabortionisrelatedtotheexistenceofACA and AsAb． [Keywords] Abortion，habitual；Infertility，female；Anticardiolipinantibody；Ant