IL-27：保持免疫平衡的重要因子.pdfVIP

22 6 Vol. 22, No. 6 2010 6 Chinese Bulletin of Life Sciences Jun., 2010 1004-0374(2010)06-0539-07 IL-27 (300071) EBI-3 p28 IL-27 IL-12 (dendritic cells, DCs) DCs Toll Toll like receptor TLR MyD88IRF3c-Rel JNK IL-27 IL-27 WSX-1 gp130 IL-27 IL-27 STAT1/STAT3 naïve T Th1 Th2 Th17 Foxp3+ Treg B DCs Th1 IL-27 IL-27 M HC IL-27 I L - 2 7 T B R392.11 A IL-27: important factor to keep immune balance XIA Si-yuan, ZHAO Li-qing, WU Zhen-zhou, YIN Zhi-nan* (College of Life Science, Nankai University, Tianjin 300071, China) Abstract IL-27 is a new member of IL-12 family, a heterodimer of EBI-3 and p28, which is mainly secreted by dendritic cells (DCs). When the Toll-like receptors on the surface of DCs are stimulated, their downstream factor MyD88, IRF3, c-Rel and JNKs are activated and induce IL-27 expression. IL-27 receptor, which is composed by WSX-1 and gp130, is expressed by lots of immunocytes or non-immunocytes. IL-27 plays an important role on the development, differentiation and function of these cells. IL-27 can induce naïve T cell differentiate to Th1 cells whereas inhibit Th2, Th17 and Foxp3+ Treg differentiation by activating STAT1/STAT3 pathway. Switch of B cell Ig isoform and DCs co-stimulatory factor expression are also influenced by IL-27. In addition, IL-27 can induce MHC molecules expression on several kinds of non-immunocytes, thus make them get the ability of antigen presentation. In the clinical research, IL-27 plays important roles in plenty kinds of inflammatory diseases, autoimmune diseases and cancers. Therefore, IL-27 may be a new target for the medicines of these diseases.